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Tinucleosomal antibodies were reported with a mutation in exon 2 of DNAse type 1 [79], however this mutation has not been confirmed in other patient populations. Recently, study of seven consanguineous families with multiple SLE affected children by linkage analysis and exome sequencing identified loss-of-function mutations in DNASE1L3 as a monogenic cause of an SLE-like syndrome [80]. A strict M

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E rats in response to the same EA treatment suggests that EA affects healthy and pathological conditions differently. This is supported by a previous study reporting that naloxone completely blocked EA analgesia in healthy rats but partly blocked EA antihyperalgesia in carrageenan-induced inflammatory rats [23]. Collectively, these studies suggest that EA works differently in healthy and patholog

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