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Ry systems that allow them to adequately regulate developmental and physiological processes in context with environmental cues. The ubiquitin proteasome pathway, which targets a great number of proteins for degradation, is cellular tool that provides the necessary flexibility to accomplish this task. Ubiquitin E3 ligases provide the needed specificity to the pathway by selectively binding to part

The observation that 70 of children diagnosed with idiopathic ASD exhibit comorbid medical, developmental or psychiatric conditions [3,6] , including intellectual disability [7] . According to one review, over 100 genes have been linked to syndromic forms of autism [8] . In addition, therepart of10.2217/epi.15.92 ?Dennis R GraysonEpigenomics (2016) 8(1), 85?ISSN 1750-PerspectiveGrayson Guidott

Impact the brain through epigenetic mechanisms. Both genetic mutations and epigenetic influences alter gene expression in different cell types of the brain. Mutations impact the expression of large numbers of genes and also have downstream consequences depending on specific pathways associated with the mutation. Environmental factors impact the expression of sets of genes by altering methylation/

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