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Complex, the cullin brings the F-box and E2 moieties into close

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Complex, the cullin brings the F-box and E2 moieties into close proximity of around 50A to facilitate transfer of UBQs to a substrate (Zheng et al., 2002b). Skp1-like proteins contain an N-terminal domain fold of around 125 amino acids, which is similar to a BTB/POZ (Broad complex, Tramtrack, Bric-a-brac/Pox virus and Zinc finger) domain (Schulman et al., 2000), and is used by Skp1 to interact wit

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