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E complexity of regulatory tools the cells has in place to

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E complexity of regulatory tools the cells has in place to control SCFTIR1/AFB activities. The F-box protein that is most closely related to the TIR1/ AFB family is CORONATINE-INSENSITIVE PROTEIN 1 (COI1; At2g39940) (Xie et al., 1998). Similar to TIR1 it contains a 16 repeat LRR motif that is critical for substrate binding. As its name implies, COI1 was originally identified in a screen for mutant
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